Name | adenosine 5'-triphosphate |
Synonyms | ATP-H striadyne triadenyl myotriphos glucobasin triphosaden Adenosine triphosphate adenosine 5'-triphosphate Adenosine-5-triphosphoric acid adenosine 5'-(tetrahydrogen triphosphate) ADENOSINE-5-TRIPHOSPHORIC ACID (ATP) pure Adenosine 5'-triphosphate, sodium salt solution 9-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-9H-purin-6-amine ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate |
CAS | 56-65-5 |
EINECS | 200-283-2 |
InChI | InChI=1/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 |
Molecular Formula | C10H16N5O13P3 |
Molar Mass | 507.18 |
Density | 1.0g/mLat 20°C |
Melting Point | 144°C (rough estimate) |
Boling Point | 951.4±75.0 °C(Predicted) |
Specific Rotation(α) | D22 -26.7° (c = 3.095) |
Flash Point | 529.2°C |
Solubility | Easily soluble in water, insoluble in ethanol, ether and other organic solvents |
Vapor Presure | 0mmHg at 25°C |
Appearance | White crystalline powder |
pKa | pK2: 4.00(-1);pK3: 6.48(-2) (25°C) |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Sensitive | Easily absorbing moisture |
Refractive Index | 1.904 |
MDL | MFCD00150755 |
In vitro study | ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner. ATP promotes neutrophil chemotaxis in vitro. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
Toxicity | dni-hmn:lym 10 mmol/L CNREA8 42,2092,82 |
Reference Show more | 1. Zhu Yahui, Cao Wenhong, Liu Zhongjia, etc. Effect of heat treatment on the formation of characteristic flavor of Chlamys farreri [J]. Food Science, 2017, 29 (20):131-138. 2. Zhang Zhengmin, Yang Yilin, Li Meilin, et al. Effects of 2 4-epibrassinolide treatment on soft rot and energy metabolism of peach fruit [J]. Food science 2019 v.40;No.594(05):215-221. 3. Fu-Na Meng, Yi-Lun Ying, Jie Yang, and Yi-Tao long analytical Chemistry 2019 91 (15), 9910-9915DOI: 10.1021/acs. Analchem.9b 01570 4. Duan, Yajie, et al. "Antifgal mechanism of Streptomyces ma. Fs‐4 on fusarium wild of banana." Journal of Applied Microbiology 130.1 (2021): 196-207. 5. Dan Li, Yanxiao Jiang, Sihan Chen, Qingnan Zhao, Yue Zhang, Wei Wang, Ying Sun, Pinyi Ma, Daqian Song, Xinghua Wang,A simple and sensitive assay of alkaline phosphatase activity in serum by fluorescent silicon nanoparticles based on inner filter effect,S 6. [IF=7.514] Saili Zhang et al."Effects of negative air ions treatment on the quality of fresh shiitake mushroom (Lentinus edodes) during storage."Food Chem. 2022 Mar;371:131200 7. [IF=6.986] Fu-Na Meng et al."A Wild-Type Nanopore Sensor for Protein Kinase Activity."Anal Chem. 2019;91(15):9910-9915 8. [IF=5.268] Huanqing Niu et al."Immobilization of a polyphosphate kinase 2 by coordinative self-assembly of his-tagged units with metal-organic frameworks and its application in ATP regeneration from AMP."Colloid Surface B. 2019 Sep;181:261 9. [IF=4.821] Peng Wan et al."Analysis of aroma-active compounds in bighead carp head soup and their influence on umami of a model soup."Microchem J. 2021 Sep;168:106436 10. [IF=3.638] Hanbo Wang et al."Methyl jasmonate induces the resistance of postharvest blueberry to gray mold caused by Botrytis cinerea."J Sci Food Agr. 2020 Aug;100(11):4272-4281 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | adenosine 5 '-triphosphate is a metabolite of adenosine, a multifunctional nucleoside triphosphate, it serves as a coenzyme for intracellular energy transfer in cells and transports chemical energy for metabolism within the cell. |
biological activity | , provides energy for metabolism while functioning as a coenzyme in the cell. ATP is an important endogenous signaling molecule in immunity and inflammation.|
Animal Model: | Four-week-old Kunming mice (18-22 g) |
Dosage: | 50 mg/kg |
Administration: | Intraperitoneal injection, before bacterial ( E. coli ) challenge |
Result: | Protected mice from bacterial infection. |
category | toxic substances |
toxicity grade | high toxicity |
Acute toxicity | intraperitoneal-rat LD50; 200 mg/kg; Intraperitoneal-mouse LD50: 2780 mg/kg |
flammability hazard characteristics | flammability; Toxic nitrogen oxide and phosphorus oxide fumes from combustion |
storage and transportation characteristics | ventilation and low temperature drying; Separate storage |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |